| Title | [Effect of Antihypertensive Drugs on Some Humoral Parameters of Endothelial Function.] |
| Author(s) | Galiavich AS, Khamidullina AR, Galiavich RA |
| Institution | Kazan. |
| Source | Kardiologiia 2009 May; 49(5):30-33. |
| Abstract | We assessed effect of antihypertensive drugs from various classes on humoral parameters of endothelial function - levels of asymmetrical dimethyl arginine (ADMA) and metabolites of nitrous oxide (MNO) - in 106 patients with I - II degree arterial hypertension before and after 2 weeks of treatment. Two weeks treatment with various antihypertensive drugs did not lead to significant changes of ADMA levels. However antihypertensive drugs from various classes produced different effects on levels of MNO. Combination antihypertensive preparation indapamide and perindopril caused significant elevation of MNO level in patients with I - II degree arterial hypertension what appears to be indirect reflection of augmentation of nitrous oxide formation and improvement of endothelial function. |
| Language | RUS |
| Pub Type(s) | JOURNAL ARTICLE
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| PubMed ID | 19463132 |
